Predictors of 30-day mortality and 90-day functional recovery after primary pontine hemorrhage

J Korean Med Sci. 2011 Jan;26(1):100-7. doi: 10.3346/jkms.2011.26.1.100. Epub 2010 Dec 22.


The factors related to death and functional recovery after primary pontine hemorrhage (PPH) in Koreans has not been well defined. The authors sought to identify independent predictors of death and functional recovery after PPH using data obtained at a single institute. Data were collected retrospectively on 281 patients with PPH admitted to the Stroke Unit at our hospital between January 1, 2000 and December 31, 2009. Multivariate logistic regression analysis was used to evaluate the associations between selected variables and 30-day mortality and 90-day functional recovery after PPH. One-hundred and ten patients (39.1%) died within 30 days of PPH and 27 patients (9.6%) achieved functional recovery within 90 days. By multivariate analysis, unconsciousness, dilated pupils, abnormal respiration, systolic blood pressure < 100 mmHg, hydrocephalus, and conservative treatment were found to be predictors of 30-day mortality, whereas consciousness, intact motor function, no history of hypertension or diabetes mellitus, intact eye movement, a hematoma volume of < 5 mL, no ventricular hemorrhage, and normally sized ventricle were found to be predictors of 90-day functional recovery. The present findings suggest that systolic hypotension of less than 100 mmHg may predict 30-day mortality and a history of underlying hypertension and diabetes mellitus may predict 90-day functional recovery.

Keywords: Intracerebral Hemorrhage; Morbidity; Mortality; Outcome; Pons; Prognosis.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Pressure
  • Brain Stem*
  • Diabetes Complications
  • Female
  • Humans
  • Hydrocephalus / complications
  • Hypertension / complications
  • Intracranial Hemorrhages / complications
  • Intracranial Hemorrhages / epidemiology
  • Intracranial Hemorrhages / mortality*
  • Logistic Models
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prognosis
  • Recovery of Function*
  • Retrospective Studies
  • Risk Factors
  • Survival Analysis
  • Time Factors
  • Unconsciousness / complications