Blood, urine, and hair kinetic analysis following an acute lead intoxication

J Anal Toxicol. 2011 Jan;35(1):60-4. doi: 10.1093/anatox/35.1.60.

Abstract

A case of lead exposure resulting from the accidental ingestion of a lead-containing solution is reported. Because of clinical management rapidly performed through chelation therapy by 2,3-dimercaptopropane sulfonate sodium and meso-2,3-dimercaptosuccinic acid, blood lead levels of this 51-year-old patient were moderate (412.9 μg/L) and no clinical symptoms were observed. Numerous blood and urine samples were collected for kinetic analysis of lead elimination. However, we report the first case in which hair samples were analyzed to determine the excretion level of lead after acute intoxication.

Publication types

  • Case Reports

MeSH terms

  • Chelating Agents / therapeutic use
  • Chelation Therapy / methods
  • Female
  • Hair / chemistry*
  • Humans
  • Kinetics
  • Lead / blood*
  • Lead / urine*
  • Lead Poisoning / diagnosis
  • Middle Aged
  • Succimer / therapeutic use*
  • Unithiol / therapeutic use*

Substances

  • Chelating Agents
  • Lead
  • Unithiol
  • Succimer