Association of visceral and subcutaneous fat with glucose intolerance, insulin resistance, adipocytokines and inflammatory markers in Asian Indians (CURES-113)

Clin Biochem. 2011 Mar;44(4):281-7. doi: 10.1016/j.clinbiochem.2010.12.015. Epub 2011 Jan 8.

Abstract

Objectives: The aim of the study was to assess the association between visceral and subcutaneous fat with glucose intolerance, adipocytokines, inflammatory markers and carotid IMT in Asian Indians.

Design and methods: Subjects with NGT (n=85), IGT (n=49) and T2DM (n=93) were randomly selected from CURES. Total abdominal, visceral and subcutaneous fat were measured using Helical CT scan. Adiponectin, hs-CRP, TNF-alpha, oxidized LDL, visfatin and leptin and IMT and insulin resistance were assessed.

Results: Total abdominal fat (p=0.041) and the visceral fat (p=0.039) but not subcutaneous fat progressively increased from NGT, IGT and T2DM subjects. With increasing quartiles of visceral fat, there was a significant increase in insulin resistance (p=0.040); significant decrease in adiponectin (p=0.043) and increase in TNF-alpha (p=0.028), hs-CRP (p=0.043), OX-LDL (p=0.034) and visfatin (p=0.040), and carotid IMT (p=0.047) was observed.

Conclusion: Visceral fat levels increased with increasing glucose intolerance and are associated with decreased levels of adiponectin and increased levels of hs-CRP, TNF-alpha, oxidized LDL, visfatin, HOMA-IR and IMT.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abdominal Fat / metabolism
  • Adipokines / blood
  • Adiponectin / blood*
  • Adiposity*
  • Adult
  • Asians
  • Biomarkers / blood
  • Blood Glucose / analysis
  • C-Reactive Protein / analysis
  • Causality
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Female
  • Glucose Intolerance / blood
  • Glucose Intolerance / epidemiology
  • Glucose Intolerance / physiopathology*
  • Glucose Tolerance Test
  • Humans
  • India / ethnology
  • Inflammation / blood
  • Insulin Resistance / ethnology
  • Intra-Abdominal Fat / metabolism*
  • Leptin / blood
  • Lipoproteins, LDL / blood
  • Male
  • Nicotinamide Phosphoribosyltransferase / blood
  • Subcutaneous Fat / metabolism
  • Tumor Necrosis Factor-alpha / blood

Substances

  • Adipokines
  • Adiponectin
  • Biomarkers
  • Blood Glucose
  • Leptin
  • Lipoproteins, LDL
  • Tumor Necrosis Factor-alpha
  • oxidized low density lipoprotein
  • C-Reactive Protein
  • Nicotinamide Phosphoribosyltransferase