Tau-tubulin kinase-1 gene variants are associated with Alzheimer's disease in Han Chinese

Neurosci Lett. 2011 Mar 10;491(1):83-6. doi: 10.1016/j.neulet.2011.01.011. Epub 2011 Jan 8.

Abstract

Tau-tubuline kinase 1 (TTBK1) is a recently discovered brain-specific protein kinase involved in tau phosphorylation at AD-related sites. A recent large study has identified significant association of two single nucleotide polymorphisms (SNPs) (rs2651206 and rs7764257) in the TTBK1 gene with late-onset Alzheimer's disease (LOAD) in Spanish. Here, we performed a case-control study to clarify whether the risk for LOAD might be influenced by these polymorphisms in a large Chinese cohort consisting of 400 patients and 388 healthy controls. The minor alleles of the rs2651206 polymorphism within TTBK1 was significantly associated with a reduced risk of LOAD (odds ratio/OR=0.69, P=0.011). Furthermore, rs2651206 polymorphism was still strongly associated with LOAD (OR=0.72, P=0.05) after adjusted for age, gender, and the apolipoprotein E (APOE) ɛ4 status. Haplotype analysis identified the TG haplotype, deriving from the two minor alleles, to decrease the risk of LOAD (OR=0.78, P=0.037). This study provides the evidence that variations in the TTBK1 gene may play an important role in the pathogenesis of sporadic LOAD in a Han Chinese population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / enzymology*
  • Alzheimer Disease / ethnology
  • Alzheimer Disease / genetics*
  • Asian Continental Ancestry Group / ethnology
  • Asian Continental Ancestry Group / genetics
  • Brain Chemistry / genetics*
  • Case-Control Studies
  • China / ethnology
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Male
  • Polymorphism, Genetic / genetics*
  • Protein-Serine-Threonine Kinases / genetics*

Substances

  • tau-tubulin kinase
  • Protein-Serine-Threonine Kinases