A nuclear magnetic resonance approach to the comparison of mucoadhesive properties of polysaccharides for ophthalmic uses

Int J Pharm. 2011 Mar 15;406(1-2):78-83. doi: 10.1016/j.ijpharm.2010.12.032. Epub 2011 Jan 8.

Abstract

Mucoadhesive properties of tamarind seed polysaccharide (TSP) and larch arabinogalactan (AG), which are developed for ophthalmic applications, were investigated by NMR spectroscopy. Polysaccharide to mucin affinities were compared by using ketotifen fumarate as low molecular weight interaction probe. Proton selective relaxation rate measurements revealed enhanced affinity of TSP to mucin with respect to AG.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adhesiveness
  • Galactans / chemistry
  • Galactans / isolation & purification
  • Galactans / pharmacology
  • Ketotifen / administration & dosage
  • Ketotifen / chemistry
  • Larix / chemistry
  • Magnetic Resonance Spectroscopy*
  • Models, Chemical
  • Mucins / chemistry*
  • Ophthalmic Solutions / chemistry*
  • Polysaccharides / chemistry*
  • Polysaccharides / isolation & purification
  • Seeds / chemistry
  • Tamarindus / chemistry

Substances

  • Galactans
  • Mucins
  • Ophthalmic Solutions
  • Polysaccharides
  • arabinogalactan
  • Ketotifen