High-dose methotrexate-induced renal dysfunction: is glucarpidase necessary for rescue?

J Clin Oncol. 2011 Mar 1;29(7):e180; author reply e181. doi: 10.1200/JCO.2010.32.8245. Epub 2011 Jan 10.
No abstract available

Publication types

  • Comment
  • Letter

MeSH terms

  • Cohort Studies
  • Dose-Response Relationship, Drug
  • Female
  • Follow-Up Studies
  • Humans
  • Kidney Function Tests
  • Male
  • Methotrexate / adverse effects*
  • Methotrexate / therapeutic use
  • Primary Prevention / methods
  • Renal Insufficiency / chemically induced
  • Renal Insufficiency / prevention & control*
  • Risk Assessment
  • Time Factors
  • Treatment Outcome
  • gamma-Glutamyl Hydrolase / administration & dosage*

Substances

  • gamma-Glutamyl Hydrolase
  • Methotrexate