A primer on a hepatocellular carcinoma bioresource bank using the cancer genome atlas guidelines: practical issues and pitfalls

World J Surg. 2011 Aug;35(8):1732-7. doi: 10.1007/s00268-010-0953-y.


Background: Since the advent of the human genome, the era of personalized genomic medicine is indisputably in progress.

Methods: In an effort to contribute to the evolving knowledge of genomic medicine, we have aimed directly at building a bioresource bank for hepatocellular carcinoma. This tumor bank is based on the rigorous guidelines set forth by the National Cancer Institute, and it offers analytes to help elucidate the mechanisms of progression from cirrhosis to malignancy, risk factors for recurrence, and applicability of current treatment options to a diverse group of people.

Conclusions: Surgeons have a privileged position between patients (and their cancer) and the benches of basic science. Thus, we offer a primer based on our own experiences, from which surgeons may take elements to build their own bioresource bank for use in collaboration with others. We highlight some practicalities and pitfalls that could be overlooked, as well as a discussion of possible solutions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Hepatocellular / genetics*
  • Carcinoma, Hepatocellular / pathology
  • Carcinoma, Hepatocellular / surgery
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Neoplastic / pathology
  • Cooperative Behavior
  • Databases, Genetic / standards*
  • Databases, Nucleic Acid / standards
  • Disease Progression
  • Forecasting
  • Genetic Predisposition to Disease / genetics
  • Genome, Human / genetics*
  • Guidelines as Topic*
  • Humans
  • Interdisciplinary Communication
  • Liver / pathology
  • Liver Cirrhosis / pathology
  • Liver Neoplasms / genetics*
  • Liver Neoplasms / pathology
  • Liver Neoplasms / surgery
  • National Cancer Institute (U.S.)*
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local / pathology
  • Precision Medicine / trends*
  • Tissue Banks / standards*
  • United States