Roles and mechanisms of microRNAs in pancreatic cancer

World J Surg. 2011 Aug;35(8):1725-31. doi: 10.1007/s00268-010-0952-z.


Pancreatic cancer (PC) is an aggressive malignancy with poor survival. The discovery of microRNAs (miRNAs) has provided a new opportunity to study the disease. Thus far, altered expression of miRNAs has been reported in a wide range of malignancies, including PC, and some miRNAs are associated with PC cell proliferation, invasion, chemoresistance, and patient survival. This review summarizes recent advances with respect to the roles and mechanisms of miRNAs in PC and discusses potential clinical applications.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Proliferation
  • Drug Resistance, Neoplasm / genetics
  • Gene Expression Regulation, Neoplastic / genetics
  • Humans
  • MicroRNAs / genetics*
  • Neoplasm Invasiveness / genetics
  • Pancreatic Neoplasms / genetics*
  • Pancreatic Neoplasms / mortality
  • Prognosis
  • Survival Rate


  • MicroRNAs