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. 2010:695:155-68.
doi: 10.1007/978-1-4419-7037-4_11.

Adult stem cels and their niches

Francesca Ferraro  1 , Cristina Lo Celso, David Scadden
Affiliations

Adult stem cels and their niches

Francesca Ferraro et al. Adv Exp Med Biol. 2010.

Abstract

Stem cells participate in dynamic physiologic systems that dictate the outcome of developmental events and organismal stress, Since these cells are fundamental to tissue maintenance and repair, the signals they receive play a critical role in the integrity of the organism. Much work has focused on stem cell identification and the molecular pathways involved in their regulation. Yet, we understand little about how these pathways achieve physiologically responsive stem cell functions. This chapter will review the state of our understanding of stem cells in the context of their microenvironment regarding the relation between stem cell niche dysfunction, carcinogenesis and aging.

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Figures

Figure 1
Figure 1
Representation of a stem cell niche: the stem cell niche is the place where humoral, neuronal, local (paracrine), positional (physical) and metabolic cues interact with each other to regulate stem cell fate. (Adapted from Scadden DT. Nature 441:1075–1079).
Figure 2
Figure 2
Stem cell niches. In this figure are shown vertebrate and invertebrate stem cell niches along with their identified components. GSC: germinal stem cell; HSC: hematopoietic stem cell; ISC: intestinal stem cell; SVZ: sub-ventricular zone; SGZ: sub-granular zone; GFAP: glial fibrillary acidic protein.
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