MRI findings in the mild type of mucopolysaccharidosis II (Hunter's syndrome)

Neuroradiology. 1990;32(4):328-30. doi: 10.1007/BF00593056.


Neuroradiological findings in a 44-year-old male with the typical mild type of Hunter's disease are reported. Cranial MRI revealed patchy areas of increased and decreased signals in T1- and T2-weighted images in the thalamus and the basal ganglia giving rise to a honey comb-like appearance as a whole. The deep white matter showed high signals in the T2-weighted image. To our knowledge, the honey comb-like appearance has never been reported in this disorder. Deposition of mucopolysaccharides and/or glycolipids and increase in fluid content seem to be responsible for these changes.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Basal Ganglia / diagnostic imaging
  • Basal Ganglia / pathology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Mucopolysaccharidosis II* / diagnosis*
  • Mucopolysaccharidosis II* / diagnostic imaging
  • Thalamus / diagnostic imaging
  • Thalamus / pathology
  • Tomography, X-Ray Computed