A case of alveolar rhabdomyosarcoma with a chromosomal translocation, t(2;13)(q37;q14)

Virchows Arch A Pathol Anat Histopathol. 1990;417(4):357-9. doi: 10.1007/BF01605789.


We report on an alveolar rhabdomyosarcoma occurring in a 17-year-old girl. Histologically, the tumour exhibited a proliferation of small, round cells and formed alveolar structures. Immunohistochemical studies of the tumour cells showed desmin and creatine kinase MM positivity. In electron-microscopic studies, the tumour cells showed an abundance of glycogen granules, and myofilaments were recognized in the cytoplasm. Chromosome analysis revealed a translocation, t(2;13)(q37;q14), which is though to be common in this subtype of rhabdomyosarcoma. Conventional ultrastructural and immunohistochemical investigations and chromosome analysis thus appear to be a highly promising combination of methods for improved pathological diagnosis of alveolar rhabdomyosarcoma.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Female
  • Humans
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / pathology
  • Pulmonary Alveoli* / pathology
  • Rhabdomyosarcoma / genetics*
  • Rhabdomyosarcoma / pathology
  • Translocation, Genetic*