Authors have examined degree of the immune response to experimentally inoculated agent in the early (6 hours) and late (7 days) phase of the organism response to thermal injury in BALB/c rats divided into two experimental groups and three control groups (only infected, only burnt and intact). Brucella abortus bovis of VA-19 species known as a good immune response stimulator in the host was i.p. inoculated in LD 50 (1 x 10(7) bact/ml). as the infective agent. Thermal injury-scalding was induced after the Art-hurson's method. Obtained results after observed brucella multiplication and spreading in blood, spleen, liver and lymph nodes as well as after determination of the phagocyte activation degree measured by the lumisol-dependent-chemiluminescence technique have pointed out that the general response to also confirm reliability of serologic diagnosis of toxoplasmosis by IgM antibody detecting in disease outbreaks. Acute acquired toxoplasmosis could not be reliably diagnosed on the basis of IgG-ELISA and IgG-IIF test findings. Enzyme immunoassays-ELISA are significantly more sensitive and more specific than IIF ones.