SNARE proteins underpin insulin-regulated GLUT4 traffic

Traffic. 2011 Jun;12(6):657-64. doi: 10.1111/j.1600-0854.2011.01163.x. Epub 2011 Feb 8.


Delivery of the glucose transporter type 4 (GLUT4) from an intracellular location to the cell surface in response to insulin represents a specialized form of membrane traffic, known to be impaired in the disease states of insulin resistance and type 2 diabetes. Like all membrane trafficking events, this translocation of GLUT4 requires members of the SNARE family of proteins. Here, we discuss two SNARE complexes that have been implicated in insulin-regulated GLUT4 traffic: one regulating the final delivery of GLUT4 to the cell surface in response to insulin and the other controlling GLUT4's intracellular trafficking.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism
  • Diabetes Mellitus, Type 2 / metabolism
  • Glucose Transporter Type 4 / metabolism*
  • Insulin / metabolism*
  • Membrane Fusion / physiology
  • Munc18 Proteins / metabolism
  • Protein Isoforms / metabolism
  • Protein Transport / physiology
  • SNARE Proteins / metabolism*
  • Signal Transduction / physiology


  • Glucose Transporter Type 4
  • Insulin
  • Munc18 Proteins
  • Protein Isoforms
  • SNARE Proteins