Axonal neuropathy with monoclonal IgG kappa that binds to a neurofilament protein

Ann Neurol. 1990 Sep;28(3):361-4. doi: 10.1002/ana.410280309.


We report a 74-year-old woman with a slowly progressive sensory motor axonal neuropathy and a monoclonal IgG-kappa that bound to a 68-kd axonal protein identified as the low molecular weight neurofilament protein. The sera of control subjects and disease controls did not bind to neurofilament protein.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Axons*
  • Electrophysiology
  • Female
  • Humans
  • Immunoblotting
  • Immunoglobulin G / metabolism*
  • Immunoglobulin kappa-Chains / metabolism*
  • Intermediate Filament Proteins / metabolism*
  • Nervous System Diseases / metabolism*
  • Nervous System Diseases / pathology
  • Nervous System Diseases / physiopathology
  • Paraproteinemias / metabolism*
  • Sural Nerve / pathology


  • Immunoglobulin G
  • Immunoglobulin kappa-Chains
  • Intermediate Filament Proteins