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1 Division of Molecular Virology and Oncology, Graduate School of Medicine, and Division of Child Health and Welfare and Division of Endocrinology and Metabolism, Faculty of Medicine, University of the Ryukyus, Nishihara, and Department of Internal Medicine, Naha Prefectural Hospital, Naha, Okinawa, and Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan, and Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio