Lipoprotein(a) and risk of myocardial infarction--genetic epidemiologic evidence of causality

Scand J Clin Lab Invest. 2011 Apr;71(2):87-93. doi: 10.3109/00365513.2010.550311. Epub 2011 Jan 13.


Elevated levels of lipoprotein(a) are associated with an increased risk of myocardial infarction. Our study aimed to test whether genetic data are consistent with this association being causal. Accordingly, we developed a high-throughput realtime PCR assay to genotype for the lipoprotein(a) kringle IV type 2 (KIV-2) repeat polymorphism in the LPA gene in > 40,000 individuals. The LPA KIV-2 genotype associated with plasma levels of lipoprotein(a) (trend p < 0.001), and the LPA KIV-2 genotype associated with risk of myocardial infarction (trend p < 0.001 to 0.03) in a manner consistent with its effect on plasma levels of lipoprotein(a). The association of LPA KIV-2 genotypes raising plasma levels of lipoprotein(a) with increased risk of myocardial infarction strongly supports a causal association of lipoprotein(a) with risk of myocardial infarction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Genotype
  • Humans
  • Kringles
  • Lipoprotein(a) / blood*
  • Lipoprotein(a) / genetics*
  • Myocardial Infarction / blood
  • Myocardial Infarction / epidemiology*
  • Myocardial Infarction / genetics*
  • Polymorphism, Genetic
  • Repetitive Sequences, Amino Acid / genetics
  • Risk Factors


  • Lipoprotein(a)