Anti-melanoma Differentiation-Associated Gene 5 Antibody Is a Diagnostic and Predictive Marker for Interstitial Lung Diseases Associated With Juvenile Dermatomyositis

J Pediatr. 2011 Apr;158(4):675-7. doi: 10.1016/j.jpeds.2010.11.033. Epub 2011 Jan 13.

Abstract

The presence of the anti-melanoma differentiation-associated gene 5 antibody was evaluated in 13 patients with juvenile dermatomyositis (JDM). The antibody was positive in 5 of the 6 patients with JDM-associated interstitial lung disease (ILD), but not in the 7 patients without ILD. This antibody is a useful marker for early diagnosis of JDM-associated ILD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Anti-Idiotypic / immunology
  • Autoantibodies / immunology
  • Child
  • Child, Preschool
  • DEAD-box RNA Helicases / immunology*
  • Dermatomyositis / complications
  • Dermatomyositis / immunology
  • Disease Progression
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Interferon-Induced Helicase, IFIH1
  • Lung Diseases, Interstitial / diagnosis*
  • Lung Diseases, Interstitial / etiology*
  • Lung Diseases, Interstitial / immunology
  • Male
  • Retrospective Studies

Substances

  • Antibodies, Anti-Idiotypic
  • Autoantibodies
  • IFIH1 protein, human
  • DEAD-box RNA Helicases
  • Interferon-Induced Helicase, IFIH1

Supplementary concepts

  • Amyopathic dermatomyositis