Type 2 Diabetes as an Inflammatory Disease

Nat Rev Immunol. 2011 Feb;11(2):98-107. doi: 10.1038/nri2925. Epub 2011 Jan 14.

Abstract

Components of the immune system are altered in obesity and type 2 diabetes (T2D), with the most apparent changes occurring in adipose tissue, the liver, pancreatic islets, the vasculature and circulating leukocytes. These immunological changes include altered levels of specific cytokines and chemokines, changes in the number and activation state of various leukocyte populations and increased apoptosis and tissue fibrosis. Together, these changes suggest that inflammation participates in the pathogenesis of T2D. Preliminary results from clinical trials with salicylates and interleukin-1 antagonists support this notion and have opened the door for immunomodulatory strategies for the treatment of T2D that simultaneously lower blood glucose levels and potentially reduce the severity and prevalence of the associated complications of this disease.

Publication types

  • Review

MeSH terms

  • Apoptosis
  • Cell Hypoxia
  • Clinical Trials as Topic
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / immunology*
  • Diabetes Mellitus, Type 2 / metabolism*
  • Humans
  • Inflammation / drug therapy
  • Inflammation / immunology*
  • Inflammation / metabolism*
  • Insulin / metabolism
  • Insulin / pharmacology
  • Interleukin-1 / antagonists & inhibitors
  • Interleukin-1 / metabolism
  • MAP Kinase Kinase 4 / metabolism
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / metabolism
  • Receptors, Interleukin-1 / antagonists & inhibitors
  • Receptors, Interleukin-1 / metabolism

Substances

  • Insulin
  • Interleukin-1
  • NF-kappa B
  • Receptors, Interleukin-1
  • MAP Kinase Kinase 4