The physiological function of store-operated calcium entry

Neurochem Res. 2011 Jul;36(7):1157-65. doi: 10.1007/s11064-010-0383-0. Epub 2011 Jan 14.


Store-operated Ca(2+) entry is a process whereby the depletion of intracellular Ca(2+) stores signals the opening of plasma membrane Ca(2+) channels. It has long been thought that the main function of store-operated Ca(2+) entry was the replenishment of intracellular Ca(2+) stores following their discharge during intracellular Ca(2+) signaling. Recent results, however, suggest that the primary function of these channels may be to provide direct Ca(2+) signals to recipients localized to spatially restricted areas close to the sites of Ca(2+) entry in order to initiate specific signaling pathways.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channels / physiology*
  • Calcium Signaling / physiology
  • Cell Adhesion Molecules / physiology
  • Drosophila Proteins / physiology
  • Humans
  • Inositol 1,4,5-Trisphosphate Receptors / physiology
  • Membrane Proteins / physiology
  • ORAI1 Protein
  • Stromal Interaction Molecule 2
  • TRPC Cation Channels / physiology


  • Calcium Channels
  • Cell Adhesion Molecules
  • Drosophila Proteins
  • Inositol 1,4,5-Trisphosphate Receptors
  • Membrane Proteins
  • ORAI1 Protein
  • STIM2 protein, human
  • Stromal Interaction Molecule 2
  • TRPC Cation Channels
  • olf186-F protein, Drosophila
  • Calcium