Risk factors for colorectal polyps: findings from a Greek case-control study

Rev Med Chir Soc Med Nat Iasi. Jul-Sep 2010;114(3):662-70.

Abstract

There is a body of evidence showing that several lifestyle and dietary factors are associated with colorectal polyps' formation; however, the magnitude of this association in diverse populations remains unclear. The aim of this study was to investigate this association in a Greek sample.

Material and method: The study comprised of 52 subjects with histologically confirmed advanced colorectal polyps and 52 healthy controls. Data concerning lifestyle and dietary factors were collected using a validated questionnaire. Logistic regression analysis was used to estimate odds ratios and 95% confidence intervals after adjustment for potential confounders.

Results: Physical activity level (95% CI 0.032-0.953, P = 0.044) and consumption of yoghurt (95% CI 0.969-0.996, P = 0.024), cheese (95% CI 0.932-0.996, P = 0.030), fish (95% CI 0.782-0.964, P = 0.008), vegetables (95% CI 0.965-0.998, P = 0.029), and garlic (95% CI 0.005-0.671, P = 0.022) were inversely associated with colorectal polyps. Increasing age (95% CI 1.005-1.231, P = 0.039) and central obesity (95% CI 1.001-1.019, P = 0.025) were strongly associated with their presence.

Conclusion: Our study indicates that a cluster of modifiable risk factors have significant impact on colorectal polyps' occurrence in Greek population.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Alcohol Drinking / adverse effects
  • Body Mass Index
  • Case-Control Studies
  • Colonic Polyps / epidemiology
  • Colonic Polyps / etiology*
  • Colonic Polyps / prevention & control
  • Colorectal Neoplasms / etiology
  • Diet / adverse effects*
  • Female
  • Greece / epidemiology
  • Humans
  • Life Style*
  • Male
  • Middle Aged
  • Obesity / complications
  • Risk Factors
  • Sampling Studies
  • Smoking / adverse effects
  • Statistics, Nonparametric
  • Surveys and Questionnaires