The use of fresh-frozen bone in oral surgery: a clinical study of 14 consecutive cases

Blood Transfus. 2011 Jan;9(1):41-5. doi: 10.2450/2010.0130-09.


Background: Although autologous bone is considered the gold standard among the grafting materials used in implant therapy, it does have a number of drawbacks, in particular morbidity at the site of donation and the limited amount of bone available. To overcome these limitations a number of alternative bone materials have been employed in the last few years. In this study we report the results of the use of homologous fresh-frozen bone from a tissue bank in patients undergoing reconstruction of bone defects in the oral cavity.

Material and methods: Between June 2004 and October 2008, 14 consecutive patients underwent bone reconstruction with fresh-frozen bone from a tissue bank. Four to eight months after surgery, implants were placed in the newly formed bone.

Results: No problems were recorded during the post-operative course. In all cases treatment was successful and osteointegrated implants were placed in the newly formed bone after 4-8 months. All implants showed good osteointegration (100% overall success rate, mean follow-up 20 months), allowing loading with a fixed cemented prosthesis.

Conclusions: Our results support the previous findings that homologous fresh-frozen bone can be considered a valid alternative to autologous bone for the reconstruction of bone defects in the oral cavity in patients undergoing implant therapy.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Bone Transplantation / methods*
  • Cryopreservation*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Oral Surgical Procedures*
  • Retrospective Studies
  • Transplantation, Autologous
  • Transplantation, Homologous