Comparative study of the effect of antiretroviral therapy on benign lymphoepithelial cyst of parotid glands and ranulas in HIV-positive patients

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Feb;111(2):205-10. doi: 10.1016/j.tripleo.2010.09.067.


Objective: This study's aim was to assess the effect of highly active antiretroviral drugs (HAART) on benign lymphoepithelial cysts (BLEC) of the parotid and ranulas.

Study design: The records of 10 HIV-positive patients who presented with BLEC were reviewed, and 14 HIV-positive patients who presented with ranulas were prospectively enrolled. Patients in both groups received the same combination of HAART and were clinically evaluated for the first 3 months. Patients with ranulas were followed for an additional 3 months. A clinical reduction in the size of the lesions was considered to be a positive outcome.

Results: All parotid glands with BLEC resolved within 3 months. No positive results were observed in ranulas during the first 3 months. However, some of the ranulas displayed a positive result after the initial 3 months of HAART.

Conclusions: In contrast to BLEC, ranulas in HIV-positive patients seem to present a mixed and delayed response to HAART.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Antiretroviral Therapy, Highly Active*
  • Child
  • Child, Preschool
  • Cysts / complications
  • Cysts / drug therapy*
  • Cysts / virology
  • Female
  • Follow-Up Studies
  • HIV Seropositivity / complications*
  • Humans
  • Lymphatic Diseases / complications
  • Lymphatic Diseases / drug therapy*
  • Lymphatic Diseases / virology
  • Male
  • Middle Aged
  • Parotid Diseases / complications
  • Parotid Diseases / drug therapy*
  • Parotid Diseases / virology
  • Prospective Studies
  • Ranula / complications
  • Ranula / drug therapy*
  • Ranula / virology
  • Retrospective Studies
  • Treatment Outcome
  • Young Adult