Japanese encephalitis virus: from genome to infectome

Microbes Infect. 2011 Apr;13(4):312-21. doi: 10.1016/j.micinf.2011.01.002. Epub 2011 Jan 14.


Japanese encephalitis virus (JEV) is an arbovirus belonging to the family Flaviviridae. It is maintained in a zoonotic cycle involving pigs, ardeid birds and Culex species of mosquitoes. Humans are accidental/dead end hosts of JEV infection because they cannot sustain high viral titers. Factors affecting the clinical manifestations and pathogenesis of JEV infection are not well understood. Though, vaccines are currently available against JEV, it has to be further improved. Here we review the literature on the JEV life cycle, pathogenesis and host immune responses to JEV infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Encephalitis Virus, Japanese / classification
  • Encephalitis Virus, Japanese / genetics*
  • Encephalitis Virus, Japanese / immunology*
  • Encephalitis Virus, Japanese / pathogenicity
  • Encephalitis, Japanese / pathology*
  • Encephalitis, Japanese / prevention & control
  • Encephalitis, Japanese / therapy
  • Genome, Viral / genetics
  • Humans
  • Immunity
  • Virus Replication / physiology