Necrotizing Enterocolitis Is Associated With Neonatal Intestinal Injury

J Pediatr Surg. 2011 Jan;46(1):81-5. doi: 10.1016/j.jpedsurg.2010.09.069.


Purpose: We hypothesized that a subset of premature newborns has subclinical, intestinal mucosal compromise that predisposes to the development of necrotizing enterocolitis (NEC) days or weeks later.

Methods: Fifty-five newborns of 23 to 36 weeks' gestational age were identified, and urine was collected over the first 90 hours of life. The urinary concentration of intestinal fatty acid binding protein (iFABP(u)), a sensitive marker for intestinal injury, was determined. The diagnosis of NEC was based upon clinical condition, pathology, and/or imaging findings.

Results: Neonatal iFABP(u) exceeded 800 pg/mL in 27 subjects, including 9 of 9 who subsequently developed stage 2 or 3 NEC. This degree of iFABP(u) elevation, but not asphyxia, was significantly associated with the development of NEC (P < .01).

Conclusion: In this population of premature newborns, there was a substantial incidence of intestinal mucosal compromise. All infants who subsequently developed stage 2 or 3 NEC had an elevated iFABP(u). This finding suggests a model for the pathogenesis of some cases of NEC, whereby perinatal mucosal injury predisposes to further damage when feedings are initiated. In addition, neonatal iFABP(u) assessment may represent a tool to identify infants at the highest risk for NEC and allow for the institution of focused, preventive measures.

Publication types

  • Comparative Study

MeSH terms

  • Asphyxia Neonatorum / complications
  • Biomarkers / urine
  • Creatinine / urine
  • Enterocolitis, Necrotizing / etiology*
  • Enterocolitis, Necrotizing / metabolism
  • Enterocolitis, Necrotizing / physiopathology
  • Fatty Acid-Binding Proteins / urine
  • Female
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Infant, Premature / growth & development
  • Infant, Premature / urine
  • Intestinal Mucosa / metabolism
  • Intestinal Mucosa / physiopathology
  • Intestines / blood supply
  • Male
  • Mesenteric Vascular Occlusion / complications
  • Reperfusion Injury / complications


  • Biomarkers
  • FABP1 protein, human
  • Fatty Acid-Binding Proteins
  • Creatinine