Potential celiac disease in type 1 diabetes: a multicenter study

Diabetes Res Clin Pract. 2011 Apr;92(1):53-6. doi: 10.1016/j.diabres.2010.12.028. Epub 2011 Jan 15.


Aims: To describe the prevalence of potential celiac disease (pot-CD) in young patients with type 1 diabetes mellitus (T1DM) and characterize their clinical features.

Methods: This cross-sectional multicenter study involved 8717 T1DM patients from 31 Italian centers. Information was collected on the total number of T1DM patients, CD patients and pot-CD patients. The following data were collected on pot-CD patients: gender, age at T1DM diagnosis, age at the first CD serological positivity, presence of CD-related symptoms, presence of other autoimmune disorders and treatment with gluten free diet (GFD). One thousand-three-hundred-sixty-one patients who were positive for CD serology were the control group.

Results: CD serological positivity was found in 7.2% T1DM patients. Prevalence of pot-CD was 12.2% (n=77) among CD positive patients: symptoms were present in 12/77; a third autoimmune disorder was found in 15 patients. Prevalence of pot-CD in the control population was 8.4% (n=114; p=0.005). No difference was found with regard to clinical features. Only few symptomatic patients were on GFD both in T1DM and control patients.

Conclusions: A higher prevalence of pot-CD was found in T1DM patients, that may be ascribed to the routine screening, although the influence of genetic factors cannot be excluded.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Celiac Disease / epidemiology*
  • Celiac Disease / etiology
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / epidemiology*
  • Diet, Gluten-Free
  • Female
  • Humans
  • Infant
  • Male