Association of self-reported physical activity with laboratory markers of nutrition and inflammation: the Comprehensive Dialysis Study

J Ren Nutr. 2011 Nov;21(6):429-37. doi: 10.1053/j.jrn.2010.09.007. Epub 2011 Jan 15.


Objective: Patients on dialysis maintain extremely low levels of physical activity. Prior studies have demonstrated a direct correlation between nutrition and physical activity but provide conflicting data on the link between inflammation and physical activity. Using a cohort of patients new to dialysis from the Comprehensive Dialysis Study (CDS), we examined associations of self-reported physical activity with laboratory markers of nutrition and inflammation.

Design, setting, and patients: Between June 2005 and June 2007, CDS collected data on self-reported physical activity, nutrition, and health-related quality of life from patients starting dialysis in 296 facilities located throughout the United States. Baseline serum samples were collected from participants in a nutrition sub-study of CDS.

Measures: Serum albumin and prealbumin were measured as markers of nutrition, and C-reactive protein (CRP) and α-1-acid glycoprotein as markers of inflammation. Self-reported physical activity was characterized by the maximum activity score (MAS) and adjusted activity score (AAS) of the Human Activity Profile.

Results: The mean age of participants in the analytic cohort (n = 201) was 61 years. The MAS and AAS were below the 10th and first percentile, respectively, in comparison with healthy 60 year-old norms. Both activity scores were directly correlated with albumin (r(2) = 0.3, P < .0001) and prealbumin (r(2) = 0.3, P < .0001), and inversely correlated with CRP (AAS: r(2) = -0.2, P = .01; MAS: r(2) = -0.1, P = .08). In multivariate analyses adjusting for age, gender, race/ethnicity, diabetes status, and center, both activity scores were directly correlated with prealbumin and inversely correlated with CRP.

Conclusions: Patients new to dialysis with laboratory-based evidence of malnutrition and/or inflammation are likely to report lower levels of physical activity.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Biomarkers / analysis*
  • C-Reactive Protein / analysis
  • Cohort Studies
  • Cross-Sectional Studies
  • Female
  • Humans
  • Inflammation / pathology*
  • Kidney Failure, Chronic / therapy
  • Male
  • Malnutrition
  • Middle Aged
  • Motor Activity*
  • Multivariate Analysis
  • Nutritional Status*
  • Orosomucoid / analysis
  • Prealbumin / analysis
  • Quality of Life
  • Renal Dialysis*
  • Self Report
  • Serum Albumin / analysis
  • United States


  • Biomarkers
  • Orosomucoid
  • Prealbumin
  • Serum Albumin
  • C-Reactive Protein