Serotonin receptors Therapeutic prospects in cardiovascular disease

H E Connor; P P Humphrey; W Feniuk

doi:10.1016/1050-1738(91)90039-H

Serotonin receptors Therapeutic prospects in cardiovascular disease

Trends Cardiovasc Med. 1991 Jul-Aug;1(5):205-10. doi: 10.1016/1050-1738(91)90039-H.

Authors

H E Connor¹, P P Humphrey, W Feniuk

Affiliation

¹ Pharmacology Division, Glaxo Group Research Ltd., Ware, Herts SG12 0DP, United Kingdom.

PMID: 21239312
DOI: 10.1016/1050-1738(91)90039-H

Abstract

Serotonin is widely distributed throughout the body, can have potent and profound effects on the cardiovascular system, and may be involved in the pathophysiology of several cardiovascular disease states. Recent advances in the classification of serotonin receptors, along with the identification of selective drug tools for some of these receptor types, enables the putative role of different serotonin receptor subtypes in both the etiology and treatment of disease states to be explored. This review considers the potential therapeutic application of selective serotonin receptor agonists and antagonists in cardiovascular disease.