Leukocyte adhesion molecules and myocardial ischemia

Trends Cardiovasc Med. 1991 May-Jun;1(4):167-70. doi: 10.1016/1050-1738(91)90023-8.


Current evidence strongly indicates that neutrophils contribute to the injury seen after ischemia and reperfusion of various tissues. Potentially important therapeutic targets are the specific adhesion mechanisms supporting neutrophil extravasation and secretory activity. Several such mechanisms have been characterized recently at a molecular level in vitro, and warrant investigation in relevant models of human disease.