Abstract
The natural product-like 6,6″-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apigenin / chemistry*
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Biflavonoids / chemistry*
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Binding Sites
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Cell Line, Tumor
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Computer Simulation
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Cyclopentanes / chemistry
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Drug Design
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Humans
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NEDD8 Protein
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Pyrimidines / chemistry
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Ubiquitins / antagonists & inhibitors*
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Ubiquitins / metabolism
Substances
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Biflavonoids
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Cyclopentanes
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NEDD8 Protein
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NEDD8 protein, human
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Pyrimidines
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Ubiquitins
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biapigenin
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Apigenin
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pevonedistat