Hyperadiponectinemia enhances bone formation in mice

BMC Musculoskelet Disord. 2011 Jan 17;12:18. doi: 10.1186/1471-2474-12-18.


Background: There is growing evidence that adiponectin, a physiologically active polypeptide secreted by adipocytes, controls not only adipose tissue but also bone metabolism. However, a role for adiponectin in bone development remains controversial.

Methods: We therefore investigated the endocrine effects of adiponectin on bone metabolism using 12-week-old male transgenic (Ad-Tg) mice with significant hyperadiponectinemia overexpressing human full-length adiponectin in the liver.

Results: In Ad-Tg mice, the serum level of osteocalcin was significantly increased, but the levels of RANKL, osteoprotegerin, and TRAP5b were not. Bone mass was significantly greater in Ad-Tg mice with increased bone formation. In contrast, bone resorption parameters including the number of osteoclasts and eroded surface area did not differ between Ad-Tg and their littermates.

Conclusions: These findings demonstrate that hyperadiponectinemia enhances bone formation in mice.

MeSH terms

  • Adiponectin / genetics
  • Adiponectin / physiology
  • Animals
  • Bone Development / physiology*
  • Bone and Bones / cytology
  • Bone and Bones / metabolism*
  • Humans
  • Male
  • Mice
  • Mice, Transgenic


  • ADIPOQ protein, human
  • Adiponectin