Rallying the exocyst as an autophagy scaffold

Cell. 2011 Jan 21;144(2):172-4. doi: 10.1016/j.cell.2011.01.005.


Protein scaffolds coordinate the assembly of many multicomponent signaling complexes. Bodemann et al. (2011) now show that the exocyst, a protein complex involved in tethering transport vesicles to the plasma membrane, provides an assembly and activation platform for components of the autophagy machinery via a process requiring the GTPase RalB.

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