Height at 2 and 5 years of age in children born very preterm: the EPIPAGE study

Arch Dis Child Fetal Neonatal Ed. 2011 Sep;96(5):F348-54. doi: 10.1136/adc.2010.185470. Epub 2011 Jan 17.


Objectives: To evaluate growth for children born very preterm with particular focus on those born small-for-gestational age (SGA) or with ex utero growth restraint (GR), and to identify risk factors for short stature at 5 years of age.

Study design: Population-based study of children born at less than 33 completed weeks of gestation (Étude Epidémiologique sur les Petits Ages Gestationnels (EPIPAGE)). Short stature was defined as height <-2SD on WHO growth curves. Ex utero GR was considered to have occurred in children with appropriate size for gestational age at birth and with a height and/or weight below -2SD at 2 years of corrected age. Logistic regression models were used to test associations between risk factors and short stature.

Results: The authors measured height at 5 years of age for 1,597 of 2,193 children (73%), 5.6% (95% CI 4.6 to 6.9) of whom were diagnosed as having a short stature. Height was measured at 2 and 5 years of age in 1417 children. Among these, 24% of those born SGA and 36% of those with ex utero GR (p=0.002) had a short stature at 5 years. Predictors of short stature were SGA or birth length <-2SD, maternal height ≤ 160 cm, gestational age <29 weeks and systemic corticosteroids. Breastfeeding at discharge decreased the risk of short stature.

Conclusions: Short stature at 5 years of age is common in children born preterm. The highest incidence was observed in the group with ex utero GR. Systemic steroids have a long-term impact on growth and should be used with caution. Breastfeeding at discharge appeared to be protective.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Body Height / physiology*
  • Body Weight / physiology
  • Breast Feeding / statistics & numerical data
  • Epidemiologic Methods
  • Female
  • Fetal Growth Retardation / epidemiology
  • France / epidemiology
  • Gestational Age
  • Glucocorticoids / adverse effects
  • Growth Disorders / embryology
  • Growth Disorders / epidemiology
  • Growth Disorders / etiology*
  • Growth Disorders / prevention & control
  • Humans
  • Infant, Newborn
  • Infant, Premature / growth & development*
  • Infant, Small for Gestational Age / growth & development*
  • Male
  • Young Adult


  • Glucocorticoids