Getting around PLX4032: studies turn up unusual mechanisms of resistance to melanoma drug

MeSH terms

• Antineoplastic Agents / pharmacology*
• Clinical Trials as Topic
• Drug Resistance, Neoplasm*
• Gene Expression Regulation, Enzymologic
• Gene Expression Regulation, Neoplastic
• Genes, ras / drug effects
• Humans
• Indoles / pharmacology*
• MAP Kinase Kinase Kinases / metabolism
• Melanoma / drug therapy*
• Melanoma / secondary
• Mutation*
• Proto-Oncogene Proteins / metabolism
• Proto-Oncogene Proteins B-raf / genetics
• Proto-Oncogene Proteins B-raf / metabolism*
• Proto-Oncogene Proteins c-raf / metabolism
• Receptors, Platelet-Derived Growth Factor / metabolism
• Signal Transduction / drug effects
• Sulfonamides / pharmacology*
• Time Factors
• Vemurafenib