Paget disease of the bone: does it exist in Saudi Arabia?

Ann Saudi Med. 2011 May-Jun;31(3):305-10. doi: 10.4103/0256-4947.75588.


Paget disease of the bone is a chronic disease characterized by accelerated bone turnover with abnormal repair leading to expansion, pain and deformities. The disease is common in the West, but little if any information is available on its existence in the Arab world, including Saudi Arabia. We present four cases of Saudi patients with Paget disease with variable presentations. The first case, a 63-year-old woman with a history of papillary thyroid cancer, presented with bone, shoulder and chest wall pain and foci of uptake in the ribs and skull that were thought to be metastases, indicating the possibility of diagnostic difficulty in a patient with history of malignancy. Bone biopsy confirmed the diagnosis of Paget disease. The second case was a 47-year-old asymptomatic woman with an elevated alkaline phosphatase of 427 U/L, a common presentation but at an unusual age. Plain x-rays and bone scan confirmed the diagnosis. The third case was a 43-year-old man who presented with hearing impairment and right knee osteoarthritis, unusual presentations at a young age leading to a delay in diagnosis. The fourth case was a 45-year-old man who presented with sacroiliac pain and normal biochemical values, including a normal alkaline phosphatase. Bone biopsy unexpectedly revealed features of Paget disease, which evolved over time into a classical form. A common feature in all except the first case was the relatively young age. Paget disease does exist in Saudi Arabia, and it should be considered in the differential diagnosis of similar cases.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Age Factors
  • Alkaline Phosphatase / blood*
  • Biopsy
  • Delayed Diagnosis
  • Diagnosis, Differential
  • Female
  • Humans
  • Male
  • Middle Aged
  • Osteitis Deformans / diagnosis
  • Osteitis Deformans / epidemiology
  • Osteitis Deformans / pathology*
  • Saudi Arabia / epidemiology


  • Alkaline Phosphatase