Natural coagulation inhibitors and active protein c resistance in preeclampsia

Clinics (Sao Paulo). 2010;65(11):1119-22. doi: 10.1590/s1807-59322010001100011.

Abstract

Introduction: The etiology of preeclampsia is not fully established. A few studies have shown a relationship between natural coagulation inhibitors and preeclampsia.

Objectives: The purpose of this study was to investigate the status of natural coagulation inhibitors and active protein C resistance (APC-R) in preeclampsia.

Patients and methods: We studied 70 women with preeclampsia recruited consecutively and 70 healthy pregnant and 70 nonpregnant women as controls. Plasma protein C (PC), free protein S (fPS), antithrombin III (ATIII) and APC-R were evaluated.

Results: ATIII values were found to be significantly lower in preeclamptic patients than in the control groups (p< 0.001). Nevertheless, there was no significant difference between the healthy pregnant and nonpregnant women groups (p=0.141). The fPS values of the preeclamptic and healthy pregnant groups were lower than that of the nonpregnant group (p< 0.001), and the fPS value of the preeclamptic pregnant women was lower than that of healthy pregnant women (p<0.001). The PC value of the preeclamptic pregnant women was lower than that of the control groups (p< 0.001). The PC value of the healthy pregnant women was lower than that of the nonpregnant women (p< 0.001). The mean APC activity values were lower in the preeclamptic patients than that of the control groups (p< 0.001, p< 0.001). The APC-R positivity rates of the preeclamptic groups were higher than that of the control groups (p<0.001).

Conclusions: This study demonstrated that ATIII, fPS, PC values and APC resistance were lower and APC-R positivity was higher in preeclamptic women than in normal pregnant and nonpregnant women.

MeSH terms

  • Adult
  • Analysis of Variance
  • Antithrombin III / analysis*
  • Blood Coagulation
  • C-Reactive Protein / analysis*
  • Case-Control Studies
  • Female
  • Humans
  • Pre-Eclampsia / blood*
  • Pre-Eclampsia / etiology
  • Pregnancy
  • Protein S / analysis*
  • Protein S Deficiency / blood
  • Risk Factors
  • Young Adult

Substances

  • Protein S
  • Antithrombin III
  • C-Reactive Protein