Factors affecting rise in the incidence of infiltrating lobular carcinoma of the breast

Isr Med Assoc J. 2010 Nov;12(11):697-700.


Background: Infiltrating ductal carcinoma and infiltrating lobular carcinoma account for more than 90% of all invrasive breast cancer histological types. The rate of lLC is reported to be increasing steadily in the United States and Europe.

Objectives: To describe the trend in the incidence of ILC in a large cohort of patients who underwent surgery in a single institution over an 18 year period. METHODS Our comprehensive database of 2175 consecutive patients with invasive breast cancer diagnosed during the period 1992-2009 served for the analysis. Several potential factors associated with lobular carcinoma as compared with ductal carcinoma were evaluated.

Results: During this period, a 2.4-fold increase in the incidence of pure ILC was noted, from 4.6% in theyears 1992-1994 to 10.9% in 2004-2006, followed by a modest decrease to 8.7% in 2007-2009. A significant association of lobular malignancies with external hormonal use was noted, including hormone replacement therapy exposure in patients diagnosed at age 50-64, and ovarian overstimulation during in vitro fertilization in those diagnosed at age 50 or less

Conclusions: Better diagnostic tools - such as the liberal use of ultrasound and magnetic resonance imaging- and more accurate pathological definition for ILC type appear to influence the changes in the incidence of ILC in the subgroups of invasive breast cancer.

MeSH terms

  • Age Distribution
  • Aged
  • Breast Neoplasms / epidemiology*
  • Carcinoma, Ductal, Breast / epidemiology*
  • Carcinoma, Lobular / epidemiology*
  • Cohort Studies
  • Female
  • Fertilization in Vitro / statistics & numerical data
  • Hormone Replacement Therapy / statistics & numerical data
  • Humans
  • Incidence
  • Israel / epidemiology
  • Middle Aged
  • Retrospective Studies
  • Risk Factors