Anaphylactic reactions to measles-mumps-rubella vaccine in three children with allergies to hen's egg and cow's milk

Acta Paediatr. 2011 Aug;100(8):e94-6. doi: 10.1111/j.1651-2227.2011.02165.x. Epub 2011 Feb 25.


Aim: Allergies to hen's egg and cow's milk are the most frequent food allergies in infancy and childhood. Current guidelines recommend safe administration of measles-mumps-rubella (MMR) vaccine in egg allergic patients.

Methods: We present three cases of anaphylaxis that we encountered after MMR vaccination in children sensitized to hen's egg and cow's milk.

Results: Even though MMR vaccine is generally known to be safe in children with egg allergy, there may still be isolated cases of anaphylaxis.

Conclusion: Therefore, we recommend that all children not only those who were sensitized to foods should receive the MMR vaccination in a setting that is equipped to deal with anaphylactic reactions. As stated by WHO in immunization safety surveillance, 'Each vaccinator must have an emergency kit with adrenaline, and be familiar with its dosage and administration'.

Publication types

  • Case Reports

MeSH terms

  • Anaphylaxis / diagnosis
  • Anaphylaxis / etiology*
  • Child
  • Egg Hypersensitivity / complications*
  • Female
  • Humans
  • Infant
  • Male
  • Measles-Mumps-Rubella Vaccine / adverse effects*
  • Milk Hypersensitivity / complications*


  • Measles-Mumps-Rubella Vaccine