Abstract
Physical activity improves learning and hippocampal neurogenesis. It is unknown whether compounds that increase endurance in muscle also enhance cognition. We investigated the effects of endurance factors, peroxisome proliferator-activated receptor δ agonist GW501516 and AICAR, activator of AMP-activated protein kinase on memory and neurogenesis. Mice were injected with GW for 7 d or AICAR for 7 or 14 d. Two weeks thereafter mice were tested in the Morris water maze. AICAR (7 d) and GW improved spatial memory. Moreover, AICAR significantly, and GW modestly, elevated dentate gyrus neurogenesis. Thus, pharmacological activation of skeletal muscle may mediate cognitive effects.
Publication types
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Research Support, N.I.H., Intramural
MeSH terms
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Adenylate Kinase / metabolism
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Aminoimidazole Carboxamide / analogs & derivatives*
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Aminoimidazole Carboxamide / pharmacology
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Animals
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Female
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Hippocampus / drug effects*
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Hippocampus / physiology
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Hypoglycemic Agents / pharmacology
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Immunohistochemistry
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Maze Learning / drug effects
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Maze Learning / physiology
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Memory / drug effects*
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Memory / physiology
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Mice
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Mice, Inbred C57BL
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Neurogenesis / drug effects*
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Neurogenesis / physiology
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PPAR delta / agonists
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Physical Conditioning, Animal / physiology
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Ribonucleotides / pharmacology*
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Spatial Behavior / drug effects
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Spatial Behavior / physiology
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Thiazoles / pharmacology*
Substances
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GW 501516
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Hypoglycemic Agents
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PPAR delta
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Ribonucleotides
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Thiazoles
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Aminoimidazole Carboxamide
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Adenylate Kinase
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AICA ribonucleotide