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Urm1 Couples Sulfur Transfer to Ubiquitin-Like Protein Function in Oxidative Stress
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- PMID: 21245332
- PMCID: PMC3033263
- DOI: 10.1073/pnas.1019043108
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Comment
Urm1 Couples Sulfur Transfer to Ubiquitin-Like Protein Function in Oxidative Stress
Proc Natl Acad Sci U S A.
Conflict of interest statement
The authors declare no conflict of interest.
Figures
Juxtaposition of Urm1 as a prokaryotic sulfur carrier and a eukaryotic UBL. The shaded areas indicate overlapping aspects of the pathways, illustrating that Urm1 seems to use features common to both ubiquitin and MoaD for its activation and conjugation. The Urm1–E2 intermediate indicated in brackets is still hypothetical but may account for the hydroxylamine sensitivity of Urm1–protein conjugates formed in response to oxidative stress.
Comment on
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Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier.Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1763-70. doi: 10.1073/pnas.1014402108. Epub 2011 Jan 5. Proc Natl Acad Sci U S A. 2011. PMID: 21209336 Free PMC article.
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