Time-kill activity of the streptogramin NXL 103 against Gram-positive and -negative bacteria

Antimicrob Agents Chemother. 2011 Apr;55(4):1787-91. doi: 10.1128/AAC.01159-10. Epub 2011 Jan 18.

Abstract

Against 33 Gram-positive and -negative bacteria, NXL 103 MICs were 0.03 to 1 μg/ml. NXL 103 was bactericidal by 12 h at 2 × MIC against all 5 pneumococci and at 2 × MIC after 24 h against all 5 group A and B β-hemolytic streptococci. NXL 103 was bactericidal against all 8 Haemophilus influenzae strains at 2 × MIC and all 5 Moraxella catarrhalis strains at 4 × MIC after 24 h but was mainly bacteriostatic against 5 methicillin-resistant Staphylococcus aureus strains. After the exposure of one strain of each species to NXL 103 for 10 daily subcultures, the MICs remained within ± 1 dilution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Gram-Negative Bacteria / drug effects*
  • Gram-Positive Bacteria / drug effects*
  • Haemophilus influenzae / drug effects
  • Microbial Sensitivity Tests
  • Staphylococcus aureus / drug effects
  • Streptococcus pneumoniae / drug effects
  • Streptogramins / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Streptogramins