Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 10, 15

Differential Effect of Corn Oil-Based Low Trans Structured Fat on the Plasma and Hepatic Lipid Profile in an Atherogenic Mouse Model: Comparison to Hydrogenated Trans Fat

Affiliations

Differential Effect of Corn Oil-Based Low Trans Structured Fat on the Plasma and Hepatic Lipid Profile in an Atherogenic Mouse Model: Comparison to Hydrogenated Trans Fat

Yun-Young Cho et al. Lipids Health Dis.

Abstract

Background: Trans fat are not desirable in many aspects on health maintenance. Low trans structured fats have been reported to be relatively more safe than trans fats.

Methods: We examined the effects of low trans structured fat from corn oil (LC), compared with high trans fat shortening, on cholesterol and fatty acid metabolism in apo E deficient mice which is an atherogenic animal model. The animals were fed a high trans fat (10% fat: commercial shortening (CS)) or a low trans fat (LC) diet for 12 weeks.

Results: LC decreased apo B and hepatic cholesterol and triglyceride concentration compared to the CS group but significantly increased plasma total cholesterol and triglyceride concentration and fecal lipids with a simultaneous increase in HDL-cholesterol level, apo A-I, and the ratio of HDL-cholesterol to total cholesterol (HTR). Reduction of hepatic lipid levels by inclusion of LC intake was observed alongside modulation of hepatic enzyme activities related to cholesterol esterification, fatty acid metabolism and fecal lipids level compared to the CS group. The differential effects of LC intake on the plasma and hepatic lipid profile seemed to be partly due to the fatty acid composition of LC which contains higher MUFA, PUFA and SFA content as well as lower content of trans fatty acids compared to CS.

Conclusions: We suggest that LC may exert a dual effect on plasma and hepatic lipid metabolism in an atherogenic animal model. Accordingly, LC, supplemented at 10% in diet, had an anti-atherogenic effect on these apo E-/- mice, and increased fecal lipids, decreased hepatic steatosis, but elevated plasma lipids. Further studies are needed to verify the exact mode of action regarding the complex physiological changes and alteration in lipid metabolism caused by LC.

Figures

Figure 1
Figure 1
Effect of supplementation of a hydrogenated trans fat and a corn-oil based low trans structured fat on HMG-CoA reductase (HMGR) and ACAT activities in apo E-/- mice : CS group (■) and LC group (□). The results represent mean ± S.E. (n = 10). Values are significantly different from the CS group according to Student's t test: *P < .05. HMGR, 3-hydroxy-3-methylglutaryl-coenzyme reductase; ACAT, acyl CoA: cholesterol acyltransferase. CS, commercial shortening; LC, low trans structured fat from corn oil
Figure 2
Figure 2
Effect of supplementation of a hydrogenated trans fat and a corn-oil based low trans structured fat on hepatic tissue morphology in apo E-/- mice. The results represent mean ± S.E. (n = 10). The results represent mean ± S.E. (n = 10). Original magnification × 100. Fat accumulation, indicated by the arrowheads, in the form of large fat droplet is present in liver. CS, commercial shortening; LC, low trans structured fat from corn oil

Similar articles

See all similar articles

Cited by 4 PubMed Central articles

References

    1. Imaizumi M, Takeda M, Fushiki T. Effects of oil intake in the conditioned place preference test in mice. Brain Res. 2000;870:150–6. doi: 10.1016/S0006-8993(00)02416-1. - DOI - PubMed
    1. Takeda M, Sawano S, Imaizumi M, Fushiki T. Preference for corn oil in olfactory-blocked mice in the conditioned place preference test and the two-bottle choice test. Life Sci. 2001;69:847–54. doi: 10.1016/S0024-3205(01)01180-8. - DOI - PubMed
    1. Kuller LH. Nutrition, lipids, and cardiovascular disease. Nutr Rev. 2006;64:S15–26. doi: 10.1111/j.1753-4887.2006.tb00230.x. - DOI - PubMed
    1. González C, Resa JM, Concha RG, Goenaga JM. Enthalpies of mixing and heat capacities of mixtures containing acetates and ketones with corn oil at 25°C. J Food Eng. 2007;79:1104–9.
    1. Kaku S, Ohkura K, Yunoki S, Nonaka M, Tachibana H, Sugano M, Yamada K. Dietary gamma-linolenic acid dose-dependently modifies fatty acid composition and immune parameters in rats. Prostaglandins Leukot Essent Fatty Acids. 2001;65:205–10. doi: 10.1054/plef.2001.0312. - DOI - PubMed

Publication types

MeSH terms

Feedback