The risk of large for gestational age across increasing categories of pregnancy glycemia

Am J Obstet Gynecol. 2011 Mar;204(3):240.e1-6. doi: 10.1016/j.ajog.2010.10.907. Epub 2011 Jan 17.


Objective: We sought to estimate the risk of large for gestational age (LGA) across categories of glucose tolerance.

Study design: In a cohort of 89,141 participants, women without gestational diabetes mellitus (GDM) were categorized by their screening and diagnostic test results; those with GDM were categorized as meeting the National Diabetes Data Group or only the American Diabetes Association (ADA) criteria. Multivariable logistic regression models estimated the risk of LGA; screening values 5.5-6.0 mmol/L comprised the referent.

Results: In women without GDM, the odds ratio for LGA was 1.89 (95% confidence interval [CI], 1.45-2.45) for fasting, 1.57 (95% CI, 1.31-1.89) for 1-hour, 1.60 (95% CI, 1.33-1.93) for 2-hour, and 1.62 (95% CI, 1.23-2.14) for 3-hour values meeting the ADA time point-specific thresholds.

Conclusion: For GDM identified in a 2-step procedure, our findings support the use of isolated abnormal fasting values according to the ADA threshold in identifying women who could benefit from treatment.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Blood Glucose
  • Diabetes, Gestational / diagnosis
  • Diabetes, Gestational / epidemiology*
  • Female
  • Fetal Macrosomia / epidemiology*
  • Fetal Macrosomia / etiology
  • Gestational Age
  • Glucose Intolerance
  • Humans
  • Hyperglycemia / complications*
  • Middle Aged
  • Pregnancy
  • Prevalence
  • Risk Factors
  • Young Adult


  • Blood Glucose