The role of G protein-coupled receptors in the pathology of Alzheimer's disease

Nat Rev Neurosci. 2011 Feb;12(2):73-87. doi: 10.1038/nrn2977.


G protein-coupled receptors (GPCRs) are involved in numerous key neurotransmitter systems in the brain that are disrupted in Alzheimer's disease (AD). GPCRs also directly influence the amyloid cascade through modulation of the α-, β- and γ-secretases, proteolysis of the amyloid precursor protein (APP), and regulation of amyloid-β degradation. Additionally, amyloid-β has been shown to perturb GPCR function. Emerging insights into the mechanistic link between GPCRs and AD highlight the potential of this class of receptors as a therapeutic target for AD.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology
  • Amyloid Precursor Protein Secretases / metabolism*
  • Amyloid beta-Peptides / metabolism*
  • Amyloid beta-Protein Precursor / metabolism*
  • Animals
  • Brain / metabolism*
  • Brain / pathology
  • Humans
  • Neurotransmitter Agents / metabolism
  • Receptors, G-Protein-Coupled / metabolism*


  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Neurotransmitter Agents
  • Receptors, G-Protein-Coupled
  • Amyloid Precursor Protein Secretases