Synthesis of MUC1 Neoglycopeptides using efficient microwave-enhanced chaotrope-assisted click chemistry

Org Biomol Chem. 2011 Mar 7;9(5):1621-6. doi: 10.1039/c0ob01043j. Epub 2011 Jan 20.


The first synthesis of click neoglycopeptide analogues of the biologically relevant MUC1 sequence is reported. In the process, microwave-enhanced chaotrope-assisted click reaction conditions that may be used on a routine basis for the synthesis of click peptide conjugates have been developed. The convergent route for the synthesis of neoglycopeptides using these reaction conditions enables the facile, rapid, and highly efficient preparation of focused neoglycopeptide libraries of defined chemical structure for biological evaluation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azides / chemistry
  • Click Chemistry
  • Glycopeptides / chemical synthesis*
  • Microwaves
  • Molecular Structure
  • Mucin-1 / chemistry*
  • Peptide Fragments / chemical synthesis*


  • Azides
  • Glycopeptides
  • Mucin-1
  • Peptide Fragments