The Abelson tyrosine kinase (c-Abl) expression on the mouse uterus and placenta during gestational period

J Mol Histol. 2011 Apr;42(2):91-6. doi: 10.1007/s10735-011-9310-1. Epub 2011 Jan 20.


c-Abl is a protein tyrosine kinase which has very important roles in signal transduction, control of the cell cycle, cell motility, proliferation, and inhibition of apoptosis. We hypothesized that c-Abl may play an important role on uterine remodeling during pre-receptive, receptive and non-receptive endometrium. Our aim is to investigate the expression of c-Abl protein tyrosine kinase in uterine remodeling and placental development in mouse gestational stage. We performed c-Abl immunohistochemistry on mouse uterine tissue sections on days 1-9, 11, 13, and 15 of pregnancy. c-Abl was highly upregulated in the uterine luminal epithelium and other endometrial structures including glands and blood vessels in pre-receptive and receptive endometrium. Therefore these results demonstrate a role for c-Abl in uterine remodeling during decidualization, implantation, and placentation throughout gestation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blastocyst / cytology
  • Blastocyst / metabolism
  • Ectoderm / metabolism
  • Endometrium / cytology
  • Endometrium / metabolism*
  • Epithelial Cells / metabolism
  • Female
  • Mice
  • Mice, Inbred BALB C
  • Myometrium / cytology
  • Myometrium / metabolism
  • Placenta / cytology
  • Placenta / metabolism*
  • Pregnancy
  • Proto-Oncogene Proteins c-abl / metabolism*
  • Trophoblasts / metabolism


  • Proto-Oncogene Proteins c-abl