Acute renal failure in severe pancreatitis: A population-based study

Ups J Med Sci. 2011 May;116(2):155-9. doi: 10.3109/03009734.2010.547636. Epub 2011 Jan 20.


Introduction: Acute pancreatitis (AP) is a common illness with varied mortality and morbidity. Patients with AP complicated with acute renal failure (ARF) have higher mortality than patients with AP alone. Although ARF has been proposed as a leading mortality cause for AP patients admitted to the ICU, few studies have directly analyzed the relationship between AP and ARF.

Methods: We performed a retrospective study using the population-based database from the Taiwan National Health Insurance Research Database (NHIRD). In the period from 1 January 2005 to 31 December 2005, every patient with AP admitted to the ICU was included and assessed for the presence of ARF and mortality risk.

Results: In year 2005, there were a total of 221,101 admissions to the ICU. There were 1,734 patients with AP, of which 261 (15.05%) patients also had a diagnosis of ARF. Compared to sepsis and other critical illness, patients with AP had a higher risk of having a diagnosis of ARF, and patients with both diagnoses had a higher mortality rate in the same ICU hospitalization.

Conclusion: AP is associated with a higher risk of ARF, and, when both conditions exist, a higher risk of mortality is present.

MeSH terms

  • Acute Kidney Injury / etiology*
  • Acute Kidney Injury / mortality
  • Adolescent
  • Adult
  • Aged
  • Female
  • Humans
  • Intensive Care Units
  • Male
  • Middle Aged
  • Pancreatitis / complications*
  • Retrospective Studies