Personal practice: how we manage the risk of bleeding and thrombosis in children and young adults with acute lymphoblastic leukaemia

Br J Haematol. 2011 Mar;152(5):505-11. doi: 10.1111/j.1365-2141.2010.08446.x. Epub 2011 Jan 19.


Bleeding and thrombosis are not infrequent problems in children receiving treatment for acute lymphoblastic leukaemia (ALL). The exact frequency varies with age, co-morbidity and treatment schedule, but the risk is highest in the first few weeks of treatment when disease and treatment-related haemostatic abnormalities prevail. Recommendations for prevention and management are lacking due to a weak evidence base, resulting in considerable variation in practice. This article describes our personal practice in this area with reference to the available literature on the subject.

Publication types

  • Review

MeSH terms

  • Child
  • Hemorrhage / etiology*
  • Hemostatic Techniques
  • Humans
  • Platelet Transfusion
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
  • Professional Practice
  • Spinal Puncture / adverse effects
  • Thrombosis / etiology*
  • Thrombosis / therapy
  • Young Adult