Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity

Cancer Cell. 2011 Jan 18;19(1):1-2. doi: 10.1016/j.ccr.2011.01.005.


Vascular normalization is an emerging concept in cancer treatment. In this issue of Cancer Cell, Rolny et al. show that histidine-rich glycoprotein normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis. Placental Growth Factor deletion in macrophages phenocopies many of these effects.

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