Hard times for oncogenic BRAF-expressing melanoma cells

Cancer Cell. 2011 Jan 18;19(1):3-4. doi: 10.1016/j.ccr.2011.01.004.


In this issue of Cancer Cell, Arozarena et al. describe that the oncogenic BRAF Val600Glu mutant, which occurs in about half of melanomas, downregulates the cGMP-hydrolysing phosphodiesterase PDE5A in melanoma cells through the ERK-MAPK cascade coupled to the POU-domain transcription factor BRN2, thereby increasing intracellular cGMP levels and promoting invasiveness.

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