Epithelioid haemangiosarcoma in the ocular tissue of horses

J Comp Pathol. 2011 May;144(4):328-33. doi: 10.1016/j.jcpa.2010.10.011. Epub 2011 Jan 19.

Abstract

Haemangiosarcomas (HSAs) are malignant tumours of endothelial cell origin. Epithelioid HSA is a variant of the histologically conventional HSA that has little or no morphological evidence of a vascular origin and has been reported rarely in domestic animals. The following report documents six cases of equine epithelioid HSA occurring in the ocular tissues of horses with a mean age of 19.8 years at the time of diagnosis. Microscopically, all of the lesions consisted of solid sheets or cords of epithelioid cells with rare narrow clefts or small spaces containing erythrocytes that were often the only feature indicating a vascular origin. On immunohistochemistry, the neoplastic cells expressed vimentin, CD31 and factor VIII-related antigen, but not cytokeratin, indicating an endothelial nature.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Biomarkers, Tumor / metabolism
  • Epithelioid Cells / metabolism
  • Epithelioid Cells / pathology*
  • Eye Neoplasms / metabolism
  • Eye Neoplasms / pathology
  • Eye Neoplasms / veterinary*
  • Hemangiosarcoma / metabolism
  • Hemangiosarcoma / pathology
  • Hemangiosarcoma / veterinary*
  • Horse Diseases / metabolism
  • Horse Diseases / pathology*
  • Horses
  • Male
  • Platelet Endothelial Cell Adhesion Molecule-1 / metabolism
  • Vimentin / metabolism
  • von Willebrand Factor / metabolism

Substances

  • Biomarkers, Tumor
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Vimentin
  • von Willebrand Factor